Behind the Science

The Science Behind Reducing Allergens in Cats

"Research shows that eggs from chickens exposed to domestic shorthair cats can reduce Fel d1 allergens. Fel d1 is the major allergen found in cats, responsible for allergic reactions in up to 95% of people with cat allergies" (Ebenezer Satyaraj and colleagues 68-73, 2019)

What Is Fel d1?

Fel d1 is the primary allergen found in cats. This protein is present in their saliva and fur, triggering allergic reactions in sensitive individuals.

How Our Product Reduces Allergens

Chickens exposed to Fel d1 produce an antibody called "IGY" that attaches to the Fel d1 protein, reducing its effectiveness as an allergen. This results in lower allergen levels in cat fur and saliva.

Our Commitment to Ethical Practices

We ensure chickens are safely exposed to Fel d1, without harm. Through supervised interactions between cats and chickens, we maximize the production of anti-Fel d1 antibodies, all while keeping both animals safe during the process.

More Than Just Allergy Relief

Our product provides more than just allergen reduction:

Rich in protein, Linoleic acid, Vitamins B2, B12, and water-soluble Vitamin A.
Helps strengthen skin and coat health.
A nutritious, cost-effective, and convenient addition to your cat’s daily diet.

Still Researching, But Promising Results

While exact allergen reduction levels are still being studied, early findings are promising. Our egg-based supplement offers your cat a wealth of nutritional benefits, alongside potential allergen reduction.

Why Your Cat Will Love It

An easy way to boost your cat’s daily nutrition.
Potential to reduce allergens while promoting skin and coat health.
An affordable, simple addition to your cat’s diet.

Ready to Make a Difference?

Shop now to give your cat the allergen-reducing benefits and nutritional support they deserve!

Our Farm and Safety Procedures

At SAFELINE Pet, we prioritize the highest-quality products for feline health, starting with ethical sourcing. Our farmers follow USDA organic guidelines and strict biosecurity measures from the VDH and CDC. They provide a nutritious diet from a local, family-owned feed supplier. Our partnering farm, home to over 20 cats, ensures ethical exposure of chickens to the Fel d1 allergen, allowing cats to naturally cohabitate while protecting the flock from pests. We uphold humane and ethical care for all animals so you can confidently care for your cat.

Avian Influenza (H5N1) Safety Measures

We recognize concerns regarding H5N1 "Bird Flu." According to the Virginia Department of Health, no cases have been detected in Virginia’s domestic animals, including in Dayton and Roanoke, where we source our eggs. SAFELINE’s facility exclusively processes chicken eggs, eliminating cross-contamination risks.

Our Safety Process:

Pasteurization: Eggs are heated to 165°F with an immersion circulator, then rapidly cooled and freeze-dried.
Biosecurity: Fully enclosed coops, visitor restrictions, rodent control, routine cleaning, PPE use, and vigilant health monitoring safeguard our chickens and cats.

Our Process

We use a proprietary sugar blend to preserve beneficial egg proteins while deactivating harmful ones. This blend supports urinary tract health and allergy relief without affecting glucose levels, making it safe for diabetic cats.

For more information regarding Avian Influenza (H5N1): VDH, CDC, USDA

Citations:

Satyaraj, E., Gardner, C., Filipi, I., Cramer, K., & Sherrill, S. (2019). Reduction of active Fel d1 from cats using an antiFel d1 egg IgY antibody. Immunity, inflammation and disease, 7(2), 68–73. doi:10.1002/iid3.244

Satyaraj, E., Li, Q., Sun, P. & Sherrill, S. (2019). Anti-Fel d 1 immunoglobulin Y antibody-containing egg ingredient lowers allergen levels in cat saliva. Journal of Feline Medicine and Surgery, 21(10), 875-881. doi: 10.1177/1098612X19861218

Karlsson, M., Kollberg, H. & Larsson, A. (2004). Chicken IgY: utilizing the evolutionary difference. World’s Poultry Science Journal, 60, 341-348. doi: 10.1079/WPS200422

Schade, R., Calzado, E.G., Sarmiento, R., Chacana, P.A., Porankiewics-Asplund, J., Terzolo, H.R., (2005). Chicken egg yolk antibodies (IgY-technology): A review of progress in production and use in research and human and veterinary medicine. Alternatives to Laboratory Animals, 33(2),129-154.

Wedner, H.J., Mantia, T., Satyaraj, E., Gardner, C., Al-Hammadi, N. & Sherrill, S. Feeding cats egg product with anti-Fel d 1 antibodies decreases environmental Fel d 1 and allergic response. Manuscript in preparation.

Rahman, S., Nguyen S.V., Icatlo, F.C., Umeda, K. & Kodama Y. (2013). Oral passive IgY-based immunotherapeutics. Human Vaccines & Immunotherapeutics, 9, 1039-1048. doi: 10.4161/hv.23383

Works great!

We recently added a third cat to the bunch after we found her in the hurricane wreckage in Oct. Since my mom has a cat allergy we kept having to buy the super expensive cat food which is like...$70 for a 12 lb bag.
I did some digging, and found this! It works the same as the expensive cat food, and the smallest one isn't having tummy troubles with it. The cats also really like the taste of it. Not to mention, 67 for a 4 month supply vs a bag that would sometimes not last the month.
So yeah 5/5 stars, thank y'all for the hard work!!

Works wonders

I’ve always been allergic to cats but grew up with them and just tolerated it. My bf never had a cat and when we rescued our cat Pepper he was sick for weeks. I thought we would have to give him up. But I ordered this and within 10 days we could see a major improvement. Now a month in, we both don’t have any allergies and get to snuggle our fur baby. We will be buying again!

It works

Wow. Started the cats on it for 3 weeks ish before moving to our new home and my partners brother who is severely allergic to cats had zero reaction upon coming to our house and even petting the cats (which he waited to do until he realized it was working). Normally you can just wear a sweater around him that has cat the slightest amount of cat hair and his eyes will start watering/ get puffy and he will continuously start clearing his throat. This stuff really works!!

Whole Egg Powder Supplements with D-mannose for cats (30 days)

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FAQ

What ingredients are in the supplement?

Simply chicken eggs exposed to cat allergens and our proprietary sugar blend. No fillers or preservatives.

When will my package arrive after placing the order?

Your package will be shipped 2-5 business days after your order is placed.

How long does it take to feel a reduction in my allergy symptoms?

After around 3 weeks of daily feeding to your cat, you may start to feel relief from your cat allergy symptoms.

What are the directions for feeding my cat the supplement?

Feed it to your cat once a day everyday. Add one scoop (one teaspoon) of the powder supplement into your cat’s wet or dry food and mix thoroughly. Add a little bit of water to the dry food if the powder supplement is not adhering. For kittens under 10 months old, mix in a half scoop (1/2 teaspoon) to their wet/dry food.

Is SaFeline pet’s food topper safe for my cat?

Yes, our product is safe for cats. It's an all-natural, simple formula made with eggs, sugar, and D-mannose (a natural sugar made from cranberries). That's it. No preservatives. No fillers. 100% natural.

How much sugar is in the product?

The sugar is added to protect the allergen-neutralizing proteins in the eggs through the freeze drying process. There is less than 1 gram of sugar in each jar. The sugar is added to protect the proteins in the egg from becoming de-natured during the freeze-drying process. 3% is the recommended sugar limit in a cat's daily diet. Our sugar amount is below this limit while still remaining effective.

What research have you done to formulate the supplement?

All of our research sources can be found on the ‘How it Works’ page here.

What safety and health measures are included in your manufacturing process?

Our farms and operations are based out of Dayton and Roanoke, Virginia. Both co-owners have professional experience in the food service industry and follow all Current Good Manufacturing Practice (CGMP), Virginia Department of Health (VDH), and Center for Disease Control (CDC) guidelines. SaFeline pet and our farmers follow biosecurity measures, including, but not limited to, sanitizing utensils before/after use, using stainless steel surfaces and materials, wearing PPE, and minimizing cross-contamination.