Behind the Science

The Science Behind Reducing Allergens in Cats

"Research shows that eggs from chickens exposed to domestic shorthair cats can reduce Fel d1 allergens. Fel d1 is the major allergen found in cats, responsible for allergic reactions in up to 95% of people with cat allergies" (Ebenezer Satyaraj and colleagues 68-73, 2019)

What Is Fel d1?

Fel d1 is the primary allergen found in cats. This protein is present in their saliva and fur, triggering allergic reactions in sensitive individuals.

How Our Product Reduces Allergens

Chickens exposed to Fel d1 produce an antibody called "IGY" that attaches to the Fel d1 protein, reducing its effectiveness as an allergen. This results in lower allergen levels in cat fur and saliva.

Our Commitment to Ethical Practices

We ensure chickens are safely exposed to Fel d1, without harm. Through supervised interactions between cats and chickens, we maximize the production of anti-Fel d1 antibodies, all while keeping both animals safe during the process.

More Than Just Allergy Relief

Our product provides more than just allergen reduction:

Rich in protein, Linoleic acid, Vitamins B2, B12, and water-soluble Vitamin A.
Helps strengthen skin and coat health.
A nutritious, cost-effective, and convenient addition to your cat’s daily diet.

Still Researching, But Promising Results

While exact allergen reduction levels are still being studied, early findings are promising. Our egg-based supplement offers your cat a wealth of nutritional benefits, alongside potential allergen reduction.

Why Your Cat Will Love It

An easy way to boost your cat’s daily nutrition.
Potential to reduce allergens while promoting skin and coat health.
An affordable, simple addition to your cat’s diet.

Ready to Make a Difference?

Shop now to give your cat the allergen-reducing benefits and nutritional support they deserve!

Our Farm and Safety Procedures

At SAFELINE Pet, we prioritize the highest-quality products for feline health, starting with ethical sourcing. Our farmers follow USDA organic guidelines and strict biosecurity measures from the VDH and CDC. They provide a nutritious diet from a local, family-owned feed supplier. Our partnering farm, home to over 20 cats, ensures ethical exposure of chickens to the Fel d1 allergen, allowing cats to naturally cohabitate while protecting the flock from pests. We uphold humane and ethical care for all animals so you can confidently care for your cat.

Avian Influenza (H5N1) Safety Measures

We recognize concerns regarding H5N1 "Bird Flu." According to the Virginia Department of Health, no cases have been detected in Virginia’s domestic animals, including in Dayton and Roanoke, where we source our eggs. SAFELINE’s facility exclusively processes chicken eggs, eliminating cross-contamination risks.

Our Safety Process:

Pasteurization: Eggs are heated to 165°F with an immersion circulator, then rapidly cooled and freeze-dried.
Biosecurity: Fully enclosed coops, visitor restrictions, rodent control, routine cleaning, PPE use, and vigilant health monitoring safeguard our chickens and cats.

Our Process

We use a proprietary sugar blend to preserve beneficial egg proteins while deactivating harmful ones. This blend supports urinary tract health and allergy relief without affecting glucose levels, making it safe for diabetic cats.

For more information regarding Avian Influenza (H5N1): VDH, CDC, USDA

Citations:

Satyaraj, E., Gardner, C., Filipi, I., Cramer, K., & Sherrill, S. (2019). Reduction of active Fel d1 from cats using an antiFel d1 egg IgY antibody. Immunity, inflammation and disease, 7(2), 68–73. doi:10.1002/iid3.244

Satyaraj, E., Li, Q., Sun, P. & Sherrill, S. (2019). Anti-Fel d 1 immunoglobulin Y antibody-containing egg ingredient lowers allergen levels in cat saliva. Journal of Feline Medicine and Surgery, 21(10), 875-881. doi: 10.1177/1098612X19861218

Karlsson, M., Kollberg, H. & Larsson, A. (2004). Chicken IgY: utilizing the evolutionary difference. World’s Poultry Science Journal, 60, 341-348. doi: 10.1079/WPS200422

Schade, R., Calzado, E.G., Sarmiento, R., Chacana, P.A., Porankiewics-Asplund, J., Terzolo, H.R., (2005). Chicken egg yolk antibodies (IgY-technology): A review of progress in production and use in research and human and veterinary medicine. Alternatives to Laboratory Animals, 33(2),129-154.

Wedner, H.J., Mantia, T., Satyaraj, E., Gardner, C., Al-Hammadi, N. & Sherrill, S. Feeding cats egg product with anti-Fel d 1 antibodies decreases environmental Fel d 1 and allergic response. Manuscript in preparation.

Rahman, S., Nguyen S.V., Icatlo, F.C., Umeda, K. & Kodama Y. (2013). Oral passive IgY-based immunotherapeutics. Human Vaccines & Immunotherapeutics, 9, 1039-1048. doi: 10.4161/hv.23383

Was Battling Severe Cat Allergy, Now Allergy is Mostly Gone!

I’ll put my short review first in case you don’t want to read too in-depth:
I had a sudden severe bout of hives, allergenic asthma, and even some light facial swelling due to my cats over the span of months. Antihistamines didn’t even seem to work. Now, after trying SaFeline for about a month, even on my worst days, my only symptoms might be slight sneezing or coughing (if I don’t take an antihistamine, but with antihistamine, all symptoms are gone, don’t even need an inhaler). I do also use an air purifier that is able to filter out particles as small as the cat dander (~2 microns), just to be safe. Great product, has helped immensely. My cats took to it immediately, no problems trying to get them to eat it.

My longer review:
I had the hives, allergenic asthma, and facial swelling for months. I had consulted a doctor because I had no prior history of ANY allergies, food or airborne, and they initially thought contact dermatitis. But the symptoms wouldn’t go away with just corticosteroids and antihistamines. As soon as I stopped either med, they came right back within a day or two. So eventually I took an allergy test and they determined that I was severely allergic to my cats, even though I’d had them for over five years without these symptoms. I refuse to get rid of them, so I was looking through different products to help me with my allergy. A famous product, Pacagen was so pricey, so I wanted an alternative with a smaller price point and stumbled upon SaFeline. Of course, I initially had my doubts, but as stated in my shorter review above, SaFeline definitely does work. As I also said in my shorter review, I do still have the mildest of symptoms, assuming I don’t take an antihistamine, however with my allergy being so severe, I wouldn’t expect a product to completely eliminate my allergy and curb its symptoms 100%. However, it definitely surpassed my expectations and I don’t even have to take the antihistamine every day like I had been. I use an air purifier as well that filters out particles as small as 2 microns to limit the amount of cat dander in my home as well.

I’ve seen reviews saying that their cats did not like the product, however from my personal experience, my cats LOVE the product. They even smelled it through the shipping box and were trying to get into it. It wouldn’t stick too well to dry food, so you might have to moisten the kibble if you only use dry food, but my cats get a meal of dry food and a meal of wet food, so I just put it in their canned food once a day.

My package arrives in about a week of when I place the order, so that’s not too bad either, just factor that in when you re-order so that your cats don’t miss any servings.

Maybe it's helping... not sure

Hi Leah, thank you for your feedback. I see you just received your order a little over a week ago. Please note that it takes around 3 weeks of once daily feeding to your cat to start noticeably feeling relief from your allergy symptoms. We look forward to hearing an update from you in the coming weeks regarding possible improvement in your allergy symptoms. Please reach out with any questions or concerns. Thank you!

Must have for that allergy in the family

I’m allergic to cats, but I love my cat and he’s heavily imprinted on me to the point I’m his cuddle partner. I’ve tried everything from Pacagen, allergy pills, and even the liveclear diet. This has been the first meal topper that my cat scampers for. He’ll actively wait for me to put the topper on the food before he starts munching and it’s the first thing he finishes all of. I can shove my nose in his face without issues because I love my cat.

Unhappy

Jar isn’t even half way full. If that is the standard amount, you need to update the description of your product. I paid for 1.7oz and got 1/3 of that.

We are so sorry that you were not satisfied with your product. In regards to your concerns, the jar is 8 ounces to leave sufficent space to hold the 1.7 ounce of powder and the scoop. One unit is portioned to last for 30 days using one scoop a day. If you are still not satisfied, we are happy to offer you a refund. Please reach out if we can assist you with any further questions or concerns.

No progress nor improvement

It takes my cat a bit to get used to it yet no improvement so far with fur dropping crazy

Hello Ran, thank you for your feedback. Please note that it takes around 3 weeks of once daily feeding to your cat to start noticeably feeling relief from your allergy symptoms. We look forward to hearing an update from you in the coming weeks regarding possible improvement in your allergy symptoms. Please reach out with any questions or concerns. Thank you.

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FAQ

What ingredients are in the supplement?

Simply chicken eggs exposed to cat allergens and our proprietary sugar blend. No fillers or preservatives.

When will my package arrive after placing the order?

Your package will be shipped 2-5 business days after your order is placed.

How long does it take to feel a reduction in my allergy symptoms?

After around 3 weeks of daily feeding to your cat, you may start to feel relief from your cat allergy symptoms.

What are the directions for feeding my cat the supplement?

Feed it to your cat once a day everyday. Add one scoop (one teaspoon) of the powder supplement into your cat’s wet or dry food and mix thoroughly. Add a little bit of water to the dry food if the powder supplement is not adhering. For kittens under 10 months old, mix in a half scoop (1/2 teaspoon) to their wet/dry food.

Is SaFeline pet’s food topper safe for my cat?

Yes, our product is safe for cats. It's an all-natural, simple formula made with eggs, sugar, and D-mannose (a natural sugar made from cranberries). That's it. No preservatives. No fillers. 100% natural.

How much sugar is in the product?

The sugar is added to protect the allergen-neutralizing proteins in the eggs through the freeze drying process. There is less than 1 gram of sugar in each jar. The sugar is added to protect the proteins in the egg from becoming de-natured during the freeze-drying process. 3% is the recommended sugar limit in a cat's daily diet. Our sugar amount is below this limit while still remaining effective.

What research have you done to formulate the supplement?

All of our research sources can be found on the ‘How it Works’ page here.

What safety and health measures are included in your manufacturing process?

Our farms and operations are based out of Dayton and Roanoke, Virginia. Both co-owners have professional experience in the food service industry and follow all Current Good Manufacturing Practice (CGMP), Virginia Department of Health (VDH), and Center for Disease Control (CDC) guidelines. SaFeline pet and our farmers follow biosecurity measures, including, but not limited to, sanitizing utensils before/after use, using stainless steel surfaces and materials, wearing PPE, and minimizing cross-contamination.